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Clinical Trials | Research study for adults with Prostate cancer

A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer (COMPPARE)

COMPPARE stands for “A Prospective COMparative Study of Outcomes with Proton and Photon RAdiation in PRostate CancEr (COMPPARE).” This study, which is funded by the Patient-Centered Outcomes Research Institute (PCORI) and approved by the University of Florida Institutional Review Board, will compare the quality of life, side effects, and cure rates for prostate cancer patients treated with proton therapy or photon therapy. We will ask 3000 men between the ages of 30-85 across the US who will be treated with either protons or photons to participate in COMPPARE. Proton therapy patients can choose to participate in a randomized trial that will evaluate whether quality of life, side effects, and prostate cancer cure rates differ between patients receiving the standard therapy versus a shorter therapy. For this study, UVA is participating as a photon therapy treatment site only Participants will answer brief surveys regarding treatment choice, quality of life, and side effects for at least 3 years. Clinic follow ups will occur 3 months, 6 months, 12 months, 18months, and then annually after treatment completion.