Clinical Trials | A Randomized Phase II Study Comparing Cytarabine + Daunorubicin (7+3) vs (Daunorubicin and Cytarabine) Liposome, Cytarabine + Daunorubicin + Venetoclax, Azacitidine + Venetoclax, and (Daunorubicin and Cytarabine) Liposome + Venetoclax in Patients Aged 59 or Younger Who Are Considered High-Risk (Adverse) Acute Myeloid Leukemia as Determined by myeloMATCH; A myeloMATCH Clinical Trial (MM1YA-S01)

The University of Virginia is participating in a clinical research study for adults ages 18 and over, who have "high risk" acute myeloid leukemia (AML) that has just been diagnosed and have not yet started treatment. AML is considered “high-risk” when it has traits that have been known to make the AML harder to treat. This study is being done to answer the following question: Can we shrink the amount of AML or get rid of it in your bone marrow and body by treating you with the standard approach of cytarabine + daunorubicin (7+3) or one of the following experimental groups: 1) cytarabine and daunorubicin with venetoclax 2) azacitidine and venetoclax, 3) daunorubicin and cytarabine liposome, or 4) daunorubicin and cytarabine liposome with venetoclax? We are doing this study because we want to find out if these approaches are better or worse than the usual approach for high-risk AML. The usual approach is defined as care most people get for high-risk AML. If you join this study, you will be on treatment for up to 56 days. After you finish your study treatment, your doctor will continue to follow your condition for 5 years and watch you for side effects. Study-related procedures that are being done beyond your standard of care will be provided at no cost to you or your insurance. Additional information can be found here: https://clinicaltrials.gov/study/NCT05554406 [email protected] The (department, division name) seeks (insert as applies: adults/men/women/adolescents/children) ages (insert) with (insert condition) for a research study. The purpose of the study is (insert purpose of study - eg.to test the effectiveness of an investigational medicine; or to find out how stress effects blood pressure.) (Optional)You may be eligible for this study if: (insert brief eligibility criteria 3 or 4 top criteria and in lay language. Do not copy eligibility criteria from the protocol) Study involves (insert procedures-examples: taking an experimental medicine/placebo, blood draws, x rays, overnight stays,) (Insert x number of visits every x (weeks, months,) each visit lasting x amount of time or give range). Insert one of the following: Study-related (insert exams, tests and experimental medication) provided at no cost. or Participant’s insurance company will be billed for medication, test,s and procedures