Clinical Trials | The UVA Department of Kinesiology seeks recreationally active, 18–30-year-olds to evaluate the impacts of Metformin on energy use during intense exercise

The UVA Department of Kinesiology seeks healthy, recreationally active adults, ages 18 to 30 for a research study. The purpose of this study is to understand the short-term use of the FDA-approved medication metformin (immediate release) on exercise capacity, fuel use during exercise (carbohydrates vs. fats), and the blood lactate response to exercise in young, healthy adults. You may be eligible for this study if you: - Exercise at least 3 days/week, at least 30-60 minutes per session, at a moderate to vigorous intensity. - Have never taken metformin. - Do not have any overt cardiovascular, metabolic, or renal disease. - If female, are premenopausal with regular menstrual cycles Study involves 5 visits spread across roughly 6 to 10 weeks. Each visit lasts about 1 – 1.5 hours. The study involves 3 maximal exercise tests and 2 high intensity exercise bouts on a stationary bike. At each visit during exercise, we will draw blood, take your blood pressure, and determine your fitness and energy use. During the study, you will also take 2, 19-day treatments (either metformin or placebo) in a random order. You will also answer questions about your health several times during the study. Study-related tests and treatments (metformin and placebo) will be provided at no cost. Please contact Emily Grammer ([email protected]).