Clinical Trials | A Phase II Single-Arm Study of Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-Small Cell Lung Cancer with N3 Lymph Node Involvement (NEO-SURG)

The University of Virginia is participating in a clinical research study for adults ages 18 and over, who have locally advanced non-small cell lung cancer (NSCLC) that has spread to lymph nodes in the chest that would otherwise preclude them from undergoing surgery. This study is investigating whether patients such as yourself with stage 3 NSCLC with involvement of lymph nodes can undergo surgery to remove the cancer after receiving treatment with chemotherapy + immunotherapy. This study is being done for two main reasons: 1. To assess the ability of cemiplimab and chemotherapy to shrink the cancer prior to surgery. 2. To see if the approach of pursuing treatment with chemotherapy plus immunotherapy followed by surgery is feasible in the management of locally advanced stage 3 NSCLC with involvement of lymph nodes on the opposite side of the chest, or same side above the collar bone. If you choose to be in this study, your participation in this study will require study visits over the course of 5 years. Each visit will last about 6-8 hours. Study-related procedures that are being done beyond your standard of care will be provided at no cost to you or your insurance. Additional information can be found here: https://clinicaltrials.gov/study/NCT06449313?term=NCT06449313&rank=1 [email protected]